He took part in only one skit, which featured him in a tree, having rabies, and being put down by another character.In the A&E television movie Wedding Wars (2006), he starred as Shel, a gay wedding planner.After just three weeks he landed his first role on General Hospital.Stamos began his acting career with the role of Blackie Parrish on the soap opera General Hospital in late January 1982, for which he was nominated for a Daytime Emmy Award in 1984.He had starring roles in the television series Thieves (2001) and Jake in Progress (2005).Both shows ran for several episodes before cancellation.Since 2005, he has been the national spokesperson for Project Cuddle.From 2005 to 2009, Stamos had a starring role on the NBC medical drama ER as Dr. In September 2009, he began playing the role of Albert in the Broadway revival of Bye Bye Birdie.
Shortly after that show was canceled, he was brought aboard as a series regular.
In 2005, Stamos guest-starred in two episodes in season 12 of ER as paramedic-turned-intern Tony Gates.
In 2006, at the start of ER's thirteenth season, he joined the cast of ER as a series regular.
Danny's best friend, Joey, also lives in the house with them. Jesse is known to be the "bad boy" at first until he falls in love with and marries Rebecca Donaldson and has twin boys, Nicky and Alex.
In 1995, after eight seasons, the series came to an end.